![]() Some would suggest that this only occurs when autogenous bone has been implanted immediately or when a bone graft substitute has been enriched with autogenous cells. A bone graft is considered osteogenic if it contains living osteogenic cells that are able to survive in the host environment. Where rhBMPs have been engineered to maintain the growth factors, the processing of DBMs causes significant variability in the amount of osteoinductive factors that remain in the final product. Only a bone graft that is preserved with an osteoinductive factor (e.g., members of the transforming growth factor family) can be considered osteoinductive. An osteoinductive bone graft ( rhBMP, formulated DBM) is defined as a material that can induce the differentiation of mesenchymal cells into osteoblasts. Resorption time, porosity, and mechanical strength can vary widely in this class of products. Whether natural ( allograft, simple demineralized bone matrix) or synthetic ( hydroxyapatite, calcium phosphate), structure is key to an osteoconductive scaffold providing a suitable workplace for bone forming cells. The way a bone grafting technology works depends on many factors including the properties of the graft itself. The novel i-FACTOR Bone Graft “ Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process. The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone. I-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. I-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. I-FACTOR™ Bone Graft: Mechanism of Action Introducing donor cells ( osteogenesis).Providing instructions to local cells ( osteoinduction). ![]()
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